Ano6^tm1.2Phep
Targeted Allele Detail

Summary

• Symbol: Ano6^tm1.2Phep
• Name: anoctamin 6; targeted mutation 1.2, Paul A Heppenstall
• MGI ID: MGI:5819282
• Synonyms: TMEM16F^-
• Gene: Ano6 Location: Chr15:95688724-95872632 bp, + strand Genetic Position: Chr15, 50.66 cM
• Alliance: Ano6^tm1.2Phep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238366
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted located 5 of exon 13, and a neomycin resistance (neor) gene flanked with two frt sites, and a loxP site were inserted 3 of exon 13. Mice were crossed with FLP-expressing and Cre-expressing transgenic mice to remove the frt flanked neoR cassette and loxP flanked exon 13, resulting in a frame-shift mutation in exon 14. (J:238366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano6 Mutation: 84 strains or lines available

References

• Original: J:238366 Batti L, et al., TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States. Cell Rep. 2016 Jun 21;15(12):2608-15
• All: 1 reference(s)