Arpc2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Arpc2^{tm1c(EUCOMM)Wtsi}
• Name: actin related protein 2/3 complex, subunit 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5819114
• Synonyms: Arpc2^f
• Gene: Arpc2 Location: Chr1:74275656-74307368 bp, + strand Genetic Position: Chr1, 38.49 cM, cytoband C3
• Alliance: Arpc2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Arpc2 gene page

Mutation origin

• Mutant Cell Line: EPD0058_1_D07
• Germline Transmission: Earliest citation of germline transmission: J:235720
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_gt0
• Mutation details: The L1L2_gt0 cassette was inserted at position 74301181 of Chromosome 1 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 74302001. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:235720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Arpc2 Mutation: 42 strains or lines available

References

• Original: J:235720 Wang PS, et al., Crucial roles of the Arp2/3 complex during mammalian corticogenesis. Development. 2016 Aug 1;143(15):2741-52
• All: 6 reference(s)