Cd276^tm1Lpc
Targeted Allele Detail

Summary

• Symbol: Cd276^tm1Lpc
• Name: CD276 antigen; targeted mutation 1, Lieping Chen
• MGI ID: MGI:5818965
• Gene: Cd276 Location: Chr9:58431583-58462316 bp, - strand Genetic Position: Chr9, 31.79 cM
• Alliance: Cd276^tm1Lpc page

Cd276^tm1Lpc/Cd276^tm1Lpc mice are resistant to collagen-induced arthritis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 and 3 (the IgV and IgC domains) were replaced with a neomycin resistance gene via homologous recombination. RT-PCR confirmed the absence of mRNA in spleen cells. (J:237700)

Generation of the Cd276^tm1Lpc allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd276 Mutation: 22 strains or lines available

References

• Original: J:237700 Luo L, et al., B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PLoS One. 2015;10(6):e0130126
• All: 1 reference(s)