Kittm2.2Ccai
Targeted Allele Detail
|
Symbol: |
Kittm2.2Ccai |
Name: |
KIT proto-oncogene receptor tyrosine kinase; targeted mutation 2, Chen-Leng Cai |
MGI ID: |
MGI:5818526 |
Synonyms: |
c-kitH2B-GFP |
Gene: |
Kit Location: Chr5:75735647-75817382 bp, + strand Genetic Position: Chr5, 39.55 cM
|
Alliance: |
Kittm2.2Ccai page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:227907
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129
|
|
Allele Type: |
|
Targeted (Null/knockout, Reporter) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A LoxP-nlacZ-4XPolyA-LoxP-H2B-GFP-FRT-Neo-FRT cassette was targeted to the start codon of kit locus with disruption of endogenous ATG by homologous recombination in ES cells. Flp-mediated recombination removed the neo selection cassette, leaving a single FRT site behind. Resulting mouse line was crossed with Cre expressing mice to remove nlacZ and 4xPloyA stop cassette.
(J:227907)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Kit Mutation: |
179 strains or lines available
|
|
Original: |
J:227907 Sultana N, et al., Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701 |
All: |
1 reference(s) |
|