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Gpr88tm1.2Ics
Targeted Allele Detail
Summary
Symbol: Gpr88tm1.2Ics
Name: G-protein coupled receptor 88; targeted mutation 1.2, Mouse Clinical Institute
MGI ID: MGI:5818030
Synonyms: Gpr88-
Gene: Gpr88  Location: Chr3:116043304-116047123 bp, - strand  Genetic Position: Chr3, 50.23 cM, cytoband G1
Alliance: Gpr88tm1.2Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:236208
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was flanked by loxP sites and an FRT site flanked neomycin resistance gene cassette with an additional loxP site was inserted downstream in intron 2. Flp-mediated recombination removed the neo cassette. Exon 2 was deleted through cre-mediated recombination, creating a knock-out allele. In situ hybridization analysis confirmed the absence of transcript in homozygous mutant brains. Furthermore, GPR88-mediated [35S]-GTPgammaS binding was abolished in the striatum, demonstrating lack of GPR88 receptor signaling in mutant mice. (J:236208)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpr88 Mutation:  16 strains or lines available
References
Original:  J:236208 Meirsman AC, et al., Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biol Psychiatry. 2016 Jun 1;79(11):917-27
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory