Gpr88^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Gpr88^tm1.1Ics
• Name: G-protein coupled receptor 88; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5818028
• Synonyms: Gpr88^fl
• Gene: Gpr88 Location: Chr3:116043304-116047123 bp, - strand Genetic Position: Chr3, 50.23 cM, cytoband G1
• Alliance: Gpr88^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and an FRT site flanked neomycin resistance gene cassette with an additional loxP site was inserted downstream in intron 2. The neo cassette was removed by Flp-mediated recombination, leaving a conditional allele with a floxed exon 2. (J:236208)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr88 Mutation: 19 strains or lines available

References

• Original: J:236208 Meirsman AC, et al., Mice Lacking GPR88 Show Motor Deficit, Improved Spatial Learning, and Low Anxiety Reversed by Delta Opioid Antagonist. Biol Psychiatry. 2016 Jun 1;79(11):917-27
• All: 5 reference(s)