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Mir96tm2.2Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Mir96tm2.2Wtsi
Name: microRNA 96; targeted mutation 2.2, Wellcome Trust Sanger Institute
MGI ID: MGI:5817459
Gene: Mir96  Location: Chr6:30169446-30169551 bp, - strand  Genetic Position: Chr6, 12.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174268
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: IMPC
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of the PGK_EM7_PuDtk_bGHpA cassette created a deletion of Chromosome 6 (Genome Build 37). This deletion eliminates the DNA sequence for this microRNA. The cassette is composed of a loxP site followed by an F3 site followed by a PGK-puromycin-delta-tk cassette, a loxP site and finally an FRT site. Recombination events removed the selection cassette.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir96 Mutation:  5 strains or lines available
References
Original:  J:174268 Prosser HM, et al., A resource of vectors and ES cells for targeted deletion of microRNAs in mice. Nat Biotechnol. 2011 Aug 7;29(9):840-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory