Rreb1^Sao
Spontaneous Allele Detail

Summary

• Symbol: Rreb1^Sao
• Name: ras responsive element binding protein 1; shaky all over
• MGI ID: MGI:5817430
• Synonyms: nm3888^-, Rreb1^nm3888, Rreb^nm3888, sao
• Gene: Rreb1 Location: Chr13:37962376-38135981 bp, + strand Genetic Position: Chr13, Syntenic
• Alliance: Rreb1^Sao page

Mutation origin

• Strain of Origin: NOD.129P2(Cg)-Il10^tm1Cgn/Dvs

Mutation description

• Allele Type: Spontaneous (Hypomorph, Modified isoform(s))
• Mutation: Insertion
• Mutation details: This heritable phenotypic marker arose spontaneously at The Jackson Laboratory. A 573-bp insertion of an ERV3 retrotransposon element in intron 4 interferes with normal splicing of one of the neural-specific transcripts of the gene. This mutation represses the normal expression of the predominant (V7) isoform in cerebellum without affecting transcription of two longer mRNAs (X2 and X4). (J:344350)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rreb1 Mutation: 164 strains or lines available

References

• Original: J:237902 Harris BS, et al., Shaky all over: a recessive mutation on Chromosome 13. MGI Direct Data Submission. 2017
• All: 2 reference(s)