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Esyt1tm1.3Tmss
Targeted Allele Detail
Nomenclature
Symbol: Esyt1tm1.3Tmss
Name: extended synaptotagmin-like protein 1; targeted mutation 1.3, Tom Moss
MGI ID: MGI:5817357
Synonyms: esyt1 delta
Gene: Esyt1  Location: Chr10:128510248-128525859 bp, - strand  Genetic Position: Chr10, 76.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:236096
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCre- and Flp-mediated recombination removed the promoter-driven neomycin selection cassette, the IRES-BetaGal reporter expression cassette and critical exons (exons 3 through 7) of the targeted KO-first, conditional ready, parental allele Esyt1tm1Tmss resulting in insertion of an FRT and a loxP site into intron 2 of the gene. (J:236096)
Expression
In Mice Carrying this Mutation: 61 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esyt1 Mutation:  28 strains or lines available
References
Original:  J:236096 Tremblay MG, et al., Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Cell Cycle. 2016 Sep;15(17):2360-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory