Il2rb^tm1Ukl
Targeted Allele Detail

Summary

• Symbol: Il2rb^tm1Ukl
• Name: interleukin 2 receptor, beta chain; targeted mutation 1, Ulf Klein
• MGI ID: MGI:5816610
• Synonyms: Il2rb^fl
• Gene: Il2rb Location: Chr15:78363456-78379471 bp, - strand Genetic Position: Chr15, 37.52 cM, cytoband E
• Alliance: Il2rb^tm1Ukl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237689
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector containing sequence encoding a promoterless eGFP minigene, a loxP site, a triple SV40 polyA site and a PGKneo cassette followed by polyA sequence, was inserted upstream of the promoter region of the targeted gene. Another loxP site followed by the PGK promoter was inserted downstream of exon 2. The entire targeted region is flanked by FRT sites. (J:237689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il2rb Mutation: 34 strains or lines available

References

• Original: J:237689 Chinen T, et al., An essential role for the IL-2 receptor in Treg cell function. Nat Immunol. 2016 Nov;17(11):1322-1333
• All: 5 reference(s)