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Dpy30tm1d(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Dpy30tm1d(KOMP)Wtsi
Name: dpy-30, histone methyltransferase complex regulatory subunit; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5812162
Synonyms: Dpy30-
Gene: Dpy30  Location: Chr17:74606469-74630939 bp, - strand  Genetic Position: Chr17, 45.64 cM
Alliance: Dpy30tm1d(KOMP)Wtsi page
IMPC: Dpy30 gene page
Mutation
origin
Mutant Cell Line:  EPD0714_4_A06
Germline Transmission:  Earliest citation of germline transmission: J:237262
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 74614423 of Chromosome 17 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 74615334. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exons. (J:237262)
Expression
In Mice Carrying this Mutation: 3 assay results
1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpy30 Mutation:  45 strains or lines available
References
Original:  J:237262 Yang Z, et al., Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells. J Exp Med. 2016 Oct 17;213(11):2349-2364
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory