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Dhpstm2d(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Dhpstm2d(EUCOMM)Wtsi
Name: deoxyhypusine synthase; targeted mutation 2d, Wellcome Trust Sanger Institute
MGI ID: MGI:5812111
Synonyms: Dhs-
Gene: Dhps  Location: Chr8:85798386-85801791 bp, + strand  Genetic Position: Chr8, 41.55 cM
Alliance: Dhpstm2d(EUCOMM)Wtsi page
IMPC: Dhps gene page
Mutation
origin
Mutant Cell Lines:  EPD0628_1_B06, EPD0628_1_C06, EPD0628_1_F05
Germline Transmission:  Earliest citation of germline transmission: J:236582
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 85798794 of Chromosome 8 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 7 at position 85801230. Exons 2-7 are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked exons 2-7. (J:236582)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhps Mutation:  21 strains or lines available
References
Original:  J:236582 Pallmann N, et al., Biological Relevance and Therapeutic Potential of the Hypusine Modification System. J Biol Chem. 2015 Jul 24;290(30):18343-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory