Dp(11Gast-Hsd17b1)1Brd
Targeted Allele Detail

Summary

• Symbol: Dp(11Gast-Hsd17b1)1Brd
• Name: duplication, Chr 11, Bradley 1; duplication, Chr 11, Allan Bradley 1
• MGI ID: MGI:5811650
• Synonyms: Dp(11)1, Dp11(1), dp(11)(gas-Hsd17b1)^Brd
• Gene: Dp(11Gast-Hsd17b1)1Brd Location: unknown Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50799
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Duplication
• Dp(11Gast-Hsd17b1)1Brd involves 43 genes/genome features (nmf148, Corn2, Gast ...) View all
• Mutation details: A loxP site was targeted into the Gast gene. A second loxP site was targeted into the Hsd17b1 gene. Transient expression of Cre recombinase in ES cells resulted in recombination between loxP sites on opposite ends of the chromosome, duplicating the 1 Mb region from Gast to Hsd17b1. (J:50799)

Tumor Data

List all tumor models in MMHCdb carrying Dp(11Gast-Hsd17b1)1Brd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dp(11Gast-Hsd17b1)1Brd Mutation: 0 strains or lines available

References

• Original: J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
• All: 3 reference(s)