Cpt1a^em1Nki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cpt1a^em1Nki
• Name: carnitine palmitoyltransferase 1a, liver; endonuclease-mediated mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:5810634
• Synonyms: Cpt1a P479L
• Gene: Cpt1a Location: Chr19:3372334-3435733 bp, + strand Genetic Position: Chr19, 3.08 cM
• Alliance: Cpt1a^em1Nki page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced a 3 bp CCC to TTG change in exon 12 resulting in a proline to leucine substitution at position 479 (P479L). (J:284256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1a Mutation: 54 strains or lines available

References

• Original: J:284256 Morkholt AS, et al., CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis. Sci Rep. 2019 Sep 16;9(1):13299
• All: 4 reference(s)