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Liastm2.1Mae
Targeted Allele Detail
Nomenclature
Symbol: Liastm2.1Mae
Name: lipoic acid synthetase; targeted mutation 2.1, Nobuyo Maeda
MGI ID: MGI:5810126
Synonyms: LiasLow
Gene: Lias  Location: Chr5:65548840-65567766 bp, + strand  Genetic Position: Chr5, 33.66 cM, cytoband C3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:236908
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsThe targeting vector consists of a loxP site, the 3' UTR sequence of the bovine growth hormone gene, a neomycin cassette and a loxP site followed by the 3'-UTR sequence of the cFos gene. Cre-mediated recombination removed the bovine growth hormone gene and neo cassette, allowing cFos to drive expression of the endogenous gene. Expression is 25% of the endogenous gene expression. (J:236908)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lias Mutation:  21 strains or lines available
Notes
ES cell line - Chemicon B/6N
References
Original:  J:236908 Xu L, et al., Influence of Different Levels of Lipoic Acid Synthase Gene Expression on Diabetic Nephropathy. PLoS One. 2016;11(10):e0163208
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory