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Sik3tm1.1Iiis
Targeted Allele Detail
Summary
Symbol: Sik3tm1.1Iiis
Name: SIK family kinase 3; targeted mutation 1.1, Masashi Yanagisawa and Hiromasa Funato
MGI ID: MGI:5806542
Synonyms: Sik3tm1.1Ksak
Gene: Sik3  Location: Chr9:45924118-46135492 bp, + strand  Genetic Position: Chr9, 25.36 cM
Alliance: Sik3tm1.1Iiis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:236598
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 12. Intron 13 was modified by single point mutation (G to A) that abolishes a splice donor site and mimics the ENU mutation in Sik3Slp. Flp-mediated recombination removed the selection cassette. (J:236598)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sik3 Mutation:  60 strains or lines available
References
Original:  J:236598 Funato H, et al., Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 2016 Nov 17;539(7629):378-383
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory