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Tg(SFTPC-CD74/ROS1)125Tno
Transgene Detail
Nomenclature
Symbol: Tg(SFTPC-CD74/ROS1)125Tno
Name: transgene insertion 125, Tetsuo Noda
MGI ID: MGI:5806502
Synonyms: CD74-ROS1
Transgene: Tg(SFTPC-CD74/ROS1)125Tno  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SFTPC-CD74/ROS1)125Tno expresses 2 genes
 
Mutation detailsA CD74 exon 6 to ROS1 exon 34 fusion cDNA bearing a FLAG-tag at the N terminal is under the control of a type 2 alveolar epithelium-specific human surfactant protein-C promoter. Three lines, 125, 151, and 026 were established. Immunoblotting analysis confirmed expression of fusion-gene product in lung tissues. (J:231770)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:231770 Inoue M, et al., Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency. Carcinogenesis. 2016 May;37(5):452-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/03/2022
MGI 6.21
The Jackson Laboratory