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Tmprss4tm1.2Hum
Targeted Allele Detail
Nomenclature
Symbol: Tmprss4tm1.2Hum
Name: transmembrane protease, serine 4; targeted mutation 1.2, Edith Hummler
MGI ID: MGI:5806232
Synonyms: Tmprss4delta, Tmprss4tm1.1Hum
Gene: Tmprss4  Location: Chr9:45172726-45204092 bp, - strand  Genetic Position: Chr9, 24.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229561
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 8 and 9. Western blot analysis confirmed the absence of protein expression in the colon. (J:229561)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmprss4 Mutation:  21 strains or lines available
References
Original:  J:229561 Keppner A, et al., Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. PLoS One. 2015;10(8):e0135224
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory