Pten^tm3.1Gle
Targeted Allele Detail

Summary

• Symbol: Pten^tm3.1Gle
• Name: phosphatase and tensin homolog; targeted mutation 3.1, Gustavo Leone
• MGI ID: MGI:5806109
• Synonyms: Pten^FV
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm3.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226418
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 8 was replaced with a modified one in which a T to G point mutation results in the amino acid substitution of valine for phenylalanine at position 341 (F341V). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon. (J:226418)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm3.1Gle

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 86 strains or lines available

References

• Original: J:226418 Caserta E, et al., Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes Dev. 2015 Aug 15;29(16):1707-20
• All: 1 reference(s)