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Targeted Allele Detail
Symbol: Mir196a-1tm1.1Wtsi
Name: microRNA 196a-1; targeted mutation 1.1, Wellcome Trust Sanger Institute
MGI ID: MGI:5805880
Synonyms: Mir196a-1tm1.1(mirKO)Wtsi
Gene: Mir196a-1  Location: Chr11:96155990-96156091 bp, + strand  Genetic Position: Chr11, 59.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:226712
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of the PGK_EM7_PuDtk_bGHpA cassette created a deletion of size 182 starting at position 96126438 and ending at position 96126620 of Chromosome 11 (Genome Build 37). This deletion eliminates the DNA sequence for this microRNA. The cassette is composed of a loxP site followed by an F3 site followed by a PGK-puromycin-delta-tk cassette, a loxP site and finally an FRT site. Cre-mediated recombination removed the selection cassette. (J:226712)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mir196a-1 Mutation:  4 strains or lines available
Original:  J:226712 Wong SF, et al., Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4884-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory