Wasf1tm1.2Kmyo
Targeted Allele Detail
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Symbol: |
Wasf1tm1.2Kmyo |
Name: |
WASP family, member 1; targeted mutation 1.2, Yong Kim |
MGI ID: |
MGI:5805826 |
Gene: |
Wasf1 Location: Chr10:40759476-40814565 bp, + strand Genetic Position: Chr10, 22.07 cM
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Alliance: |
Wasf1tm1.2Kmyo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:228804
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 4. Western blot analysis confirmed the absence of protein expression in the hippocampus.
(J:228804)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Wasf1 Mutation: |
49 strains or lines available
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Original: |
J:228804 Ceglia I, et al., APP intracellular domain-WAVE1 pathway reduces amyloid-beta production. Nat Med. 2015 Sep;21(9):1054-9 |
All: |
1 reference(s) |
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