Wasf1^tm1.2Kmyo
Targeted Allele Detail

Summary

• Symbol: Wasf1^tm1.2Kmyo
• Name: WASP family, member 1; targeted mutation 1.2, Yong Kim
• MGI ID: MGI:5805826
• Gene: Wasf1 Location: Chr10:40759476-40814565 bp, + strand Genetic Position: Chr10, 22.07 cM
• Alliance: Wasf1^tm1.2Kmyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228804
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 4. Western blot analysis confirmed the absence of protein expression in the hippocampus. (J:228804)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasf1 Mutation: 50 strains or lines available

References

• Original: J:228804 Ceglia I, et al., APP intracellular domain-WAVE1 pathway reduces amyloid-beta production. Nat Med. 2015 Sep;21(9):1054-9
• All: 1 reference(s)