Prkar1a^tm1Arte
Targeted Allele Detail

Summary

• Symbol: Prkar1a^tm1Arte
• Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:5805206
• Synonyms: PKARI Cys17Ser
• Gene: Prkar1a Location: Chr11:109540231-109560482 bp, + strand Genetic Position: Chr11, 72.33 cM
• Alliance: Prkar1a^tm1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with one in which nucleotide substitution(s) that result(s) in the amino acid substitution of serine for cysteine at position 17 (C17S). Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 2. (J:224999)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkar1a Mutation: 19 strains or lines available

References

• Original: J:224999 Burgoyne JR, et al., Deficient angiogenesis in redox-dead Cys17Ser PKARIalpha knock-in mice. Nat Commun. 2015;6:7920
• All: 3 reference(s)