Il2tm1.1(cre)Iwsh
Targeted Allele Detail
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Symbol: |
Il2tm1.1(cre)Iwsh |
Name: |
interleukin 2; targeted mutation 1.1, Makio Iwashima |
MGI ID: |
MGI:5804692 |
Synonyms: |
il-2cre |
Gene: |
Il2 Location: Chr3:37174862-37180103 bp, - strand Genetic Position: Chr3, 18.3 cM, cytoband B-C
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Alliance: |
Il2tm1.1(cre)Iwsh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:231266
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Recombinase) |
Mutation: |
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Insertion
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Il2tm1.1(cre)Iwsh expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Il2 (MGI:96548) |
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Mutation details: A targeting vector was designed to insert a cre recombinase cDNA, an frt-flanked neo cassette, and an internal ribosome entry site (IRES) into the Il2 gene just upstream of the first codon. The mice with correct targeted inserts were bred with Actin-FLPe females (on a C57BL/6 congenic background) to remove the neo selection cassette.
(J:231266)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Il2
(mouse)
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Original: |
J:231266 Yamamoto M, et al., Ontogeny and localization of the cells produce IL-2 in healthy animals. Cytokine. 2013 Mar;61(3):831-41 |
All: |
2 reference(s) |
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