Slirp^tm1.2Lrsn
Targeted Allele Detail

Summary

• Symbol: Slirp^tm1.2Lrsn
• Name: SRA stem-loop interacting RNA binding protein; targeted mutation 1.2, Nils-Goran Larsson
• MGI ID: MGI:5804681
• Gene: Slirp Location: Chr12:87490666-87496694 bp, + strand Genetic Position: Chr12, 41.67 cM, cytoband E
• Alliance: Slirp^tm1.2Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228816
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked puromycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 2. Western blot analhysis confirmed the absence of protein expression in the liver, kidney and heart. (J:228816)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slirp Mutation: 22 strains or lines available

References

• Original: J:228816 Lagouge M, et al., SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation. PLoS Genet. 2015 Aug;11(8):e1005423
• All: 3 reference(s)