Gdi1^tm1.1Myam
Targeted Allele Detail

Summary

• Symbol: Gdi1^tm1.1Myam
• Name: GDP dissociation inhibitor 1; targeted mutation 1.1, Masahiro Yamamoto
• MGI ID: MGI:5804148
• Synonyms: Gdi1^flox
• Gene: Gdi1 Location: ChrX:73348618-73355473 bp, + strand Genetic Position: ChrX, 37.97 cM, cytoband B-C1
• Alliance: Gdi1^tm1.1Myam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226569
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. A loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exons 2 through 4 floxed. (J:226569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdi1 Mutation: 14 strains or lines available

References

• Original: J:226569 Ohshima J, et al., RabGDIalpha is a negative regulator of interferon-gamma-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4581-90
• All: 1 reference(s)