Cdk8^tm1.1Gne
Targeted Allele Detail

Summary

• Symbol: Cdk8^tm1.1Gne
• Name: cyclin dependent kinase 8; targeted mutation 1.1, Genentech
• MGI ID: MGI:5804026
• Synonyms: Cdk8^loxp
• Gene: Cdk8 Location: Chr5:146168040-146239684 bp, + strand Genetic Position: Chr5, 85.19 cM
• Alliance: Cdk8^tm1.1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227730
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of eoxn 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:227730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk8 Mutation: 50 strains or lines available

References

• Original: J:227730 McCleland ML, et al., Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis. J Pathol. 2015 Dec;237(4):508-19
• All: 6 reference(s)