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Slc6a5trsl
Chemically induced Allele Detail
Nomenclature
Symbol: Slc6a5trsl
Name: solute carrier family 6 (neurotransmitter transporter, glycine), member 5; tremor with stiff legged walk
MGI ID: MGI:5796925
Gene: Slc6a5  Location: Chr7:49559894-49613604 bp, + strand  Genetic Position: Chr7, 31.71 cM, cytoband B3
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU) (Hypomorph)
Mutation:    Single point mutation
 
Mutation detailsA single G-to-A point transition at chromosome 7 position 49,917,609 (GRCm38/mm10) causes the codon change of atG to atA resulting in the change of methionine to isoleucine in a transmembrane domain, p.M278I in NP_001139485.1 and p.M2701I in NP_683733.2. (J:222308, J:235637)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a5 Mutation:  43 strains or lines available
References
Original:  J:235637 Harris BS, et al., A Viable Mouse Model of Hyperekplexia 3. MGI Direct Data Submission. 2016;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory