Gna11^m1H
Chemically induced Allele Detail

Summary

• Symbol: Gna11^m1H
• Name: guanine nucleotide binding protein, alpha 11; mutation 1, Harwell
• MGI ID: MGI:5796615
• Synonyms: Gna11^195G, Gna11^D195G
• Gene: Gna11 Location: Chr10:81364558-81380996 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gna11^m1H page

Mutation origin

• Strain of Origin: C3H/HeH
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: ENU induced an A to G substitution that results in the amino acid substitution of glycine for aspartic acid at position 195 (D195G). (J:262708)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gna11 Mutation: 21 strains or lines available

References

• Original: J:262708 Howles SA, et al., Cinacalcet corrects hypercalcemia in mice with an inactivating Galpha11 mutation. JCI Insight. 2017 Oct 19;2(20)
• All: 1 reference(s)