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Tg(Col1a2-KLF6*)1Fdmn
Transgene Detail
Nomenclature
Symbol: Tg(Col1a2-KLF6*)1Fdmn
Name: transgene insertion 1, Scott Friedman
MGI ID: MGI:5796480
Synonyms: Colalpha2(I)-KLF6-SV1
Transgene: Tg(Col1a2-KLF6*)1Fdmn  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Col1a2-KLF6*)1Fdmn expresses 1 gene
 
Mutation detailsThe transgene was designed with a mutant human KLF6 gene driven by the collagen, type I, alpha 2 (Col1a2) promoter. The KLF6 alternative splice isoform - splice variant 1 (SV1) - lacks the DNA binding domain. (J:235492)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:235492 Ghiassi-Nejad Z, et al., Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury. Hepatology. 2013 Feb;57(2):786-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory