Akap9^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Akap9^{tm1c(KOMP)Wtsi}
• Name: A kinase anchor protein 9; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5796314
• Synonyms: AKAP9^cko, Akap9^flox
• Gene: Akap9 Location: Chr5:3977410-4130204 bp, + strand Genetic Position: Chr5, 2.26 cM, cytoband A2
• Alliance: Akap9^{tm1c(KOMP)Wtsi} page
• IMPC: Akap9 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228425
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 4018123 of Chromosome 5 upstream of exon 8 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 8 at position 4019078. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, removing the lacZ sequences and neomycin selection cassette. The exon 8 thus flanked by loxP sites. (J:228425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akap9 Mutation: 182 strains or lines available

References

• Original: J:228425 Herter JM, et al., AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015;6:10182
• All: 2 reference(s)