Bmp2^tm1Rog
Targeted Allele Detail

Summary

• Symbol: Bmp2^tm1Rog
• Name: bone morphogenetic protein 2; targeted mutation 1, Melissa Rogers
• MGI ID: MGI:5796303
• Synonyms: Bmp2NeoUCS, Bmp2^UCSNeo
• Gene: Bmp2 Location: Chr2:133394079-133404805 bp, + strand Genetic Position: Chr2, 65.21 cM
• Alliance: Bmp2^tm1Rog page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242911
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A 124 base pair (bp) loxP site has replaced a PvuII restriction enzyme recognition site 76 bp past the translation termination codon, and a Pgk-neomycin phosphotransferase cassette flanked by frt sites and followed by a second loxP site has replaced an AccI recognition site 446 bp downstream of the stop codon. The loxP sites flank both the frt-flanked selection cassette and an ultraconserved sequence (UCS) in the 3' untranslated region (3'-UTR) of the mouse gene that mediates post-transcriptional repression of protein synthesis. (J:242911)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bmp2 Mutation: 26 strains or lines available

References

• Original: J:242911 Shah TA, et al., Characterization of new bone morphogenetic protein (Bmp)-2 regulatory alleles. Genesis. 2017 Jul;55(7)
• All: 1 reference(s)