Fga^tm1.1Mjfk
Targeted Allele Detail

Summary

• Symbol: Fga^tm1.1Mjfk
• Name: fibrinogen alpha chain; targeted mutation 1.1, Matthew J Flick
• MGI ID: MGI:5796268
• Synonyms: Fib^AEK
• Gene: Fga Location: Chr3:82933460-82940934 bp, + strand Genetic Position: Chr3, 36.96 cM, cytoband F1
• Alliance: Fga^tm1.1Mjfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230685
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct converted FpA residues immediately upstream of the thrombin cleavage site from E^P6GGGVR^P1 to A^P6DDDDK^P1. Cre-mediated recombination removed the floxed Hprt minigene. (J:230685)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fga Mutation: 44 strains or lines available

References

• Original: J:230685 Prasad JM, et al., Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. 2015 Oct 22;126(17):2047-58
• All: 4 reference(s)