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Fan1tm1d(KOMP)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Fan1tm1d(KOMP)Wtsi
Name: FANCD2/FANCI-associated nuclease 1; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5796264
Synonyms: Fan1deltaex3&4
Gene: Fan1  Location: Chr7:64346758-64374095 bp, - strand  Genetic Position: Chr7, 34.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:232402
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 64372070 of Chromosome 7 upstream of the critical exon 3 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 64368761. The critical exons 3 an 4 is/are thus flanked by loxP sites. Flp recombinase expression followed by subsequent cre expression resulted in a knockout allele in which the lacZ sequence, neomycin selecton cassette and exons 3 and 4 are deleted. (J:232402)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fan1 Mutation:  39 strains or lines available
References
Original:  J:232402 Thongthip S, et al., Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. Genes Dev. 2016 Mar 15;30(6):645-59
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory