Tet1^tm1.2Rao
Targeted Allele Detail

Summary

• Symbol: Tet1^tm1.2Rao
• Name: tet methylcytosine dioxygenase 1; targeted mutation 1.2, Anjana Rao
• MGI ID: MGI:5795929
• Gene: Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
• Alliance: Tet1^tm1.2Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226048
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 10. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 8 through 10. (J:226048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet1 Mutation: 147 strains or lines available

References

• Original: J:226048 Kang J, et al., Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45
• All: 1 reference(s)