Tet3^tm1.1Rao
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.1Rao
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.1, Anjana Rao
• MGI ID: MGI:5795913
• Synonyms: Tet3^fl
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.1Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226048
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:226048)

Expression

In Mice Carrying this Mutation:

8 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 60 strains or lines available

References

• Original: J:226048 Kang J, et al., Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45
• All: 19 reference(s)