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TnfBpsm1
Spontaneous Allele Detail
Nomenclature
Symbol: TnfBpsm1
Name: tumor necrosis factor; bone phenotype spontaneous mutation 1
MGI ID: MGI:5795894
Synonyms: BPSM1m
Gene: Tnf  Location: Chr17:35199381-35202007 bp, - strand  Genetic Position: Chr17, 18.59 cM
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Spontaneous (Not Applicable)
Mutation:    Viral insertion
 
Mutation detailsA retrotransposon consisting of a small interspersed element (SINE) spontaneously inserted into the 3'UTR. This insertion provides a new polyadenylation signal and terminates the mRNA prematurely. Western blot analysis confirmed increased protein expression in bone marrow-derived macrophage lysates. (J:226052)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnf Mutation:  35 strains or lines available
References
Original:  J:226052 Lacey D, et al., Spontaneous retrotransposon insertion into TNF 3'UTR causes heart valve disease and chronic polyarthritis. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9698-703
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/09/2019
MGI 6.13
The Jackson Laboratory