Akt1^tm2.1Nhy
Targeted Allele Detail

Summary

• Symbol: Akt1^tm2.1Nhy
• Name: thymoma viral proto-oncogene 1; targeted mutation 2.1, Nissim Hay
• MGI ID: MGI:5795731
• Synonyms: Akt1^f
• Gene: Akt1 Location: Chr12:112620260-112641266 bp, - strand Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
• Alliance: Akt1^tm2.1Nhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232525
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:232525)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt1 Mutation: 34 strains or lines available

References

• Original: J:232525 Yu WN, et al., Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. Cell Rep. 2015 Jul 28;12(4):610-21
• All: 3 reference(s)