Tln1tm2.1Bpet
Targeted Allele Detail
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Symbol: |
Tln1tm2.1Bpet |
Name: |
talin 1; targeted mutation 2.1, Brian G Petrich |
MGI ID: |
MGI:5793036 |
Synonyms: |
Tln1W359A |
Gene: |
Tln1 Location: Chr4:43531513-43562583 bp, - strand Genetic Position: Chr4, 23.05 cM
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Alliance: |
Tln1tm2.1Bpet page
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Germline Transmission: |
Earliest citation of germline transmission:
J:210743
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide substitutions (TGG to GCG) resulted in the amino acid substitution of alanine for tryptophan at position 359 (W359A). Cre-mediated recombination removed the floxed neomycin resistance cassette.
(J:210743)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tln1 Mutation: |
147 strains or lines available
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Original: |
J:210743 Stefanini L, et al., A talin mutant that impairs talin-integrin binding in platelets decelerates alphaIIbbeta3 activation without pathological bleeding. Blood. 2014 Apr 24;123(17):2722-31 |
All: |
2 reference(s) |
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