Rxfp1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Rxfp1^{tm1c(EUCOMM)Hmgu}
• Name: relaxin/insulin-like family peptide receptor 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5792956
• Synonyms: Rcfp1^fl
• Gene: Rxfp1 Location: Chr3:79548918-79645187 bp, - strand Genetic Position: Chr3, 34.94 cM
• Alliance: Rxfp1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Rxfp1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222129
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 79589526 of Chromosome 3 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 79590317. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice. Exon 4 is flanked by loxP sites. (J:222129)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxfp1 Mutation: 53 strains or lines available

References

• Original: J:222129 Kaftanovskaya EM, et al., Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice. Biol Reprod. 2015 Apr;92(4):91
• All: 1 reference(s)