Il17ra^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Il17ra^{tm1c(KOMP)Wtsi}
• Name: interleukin 17 receptor A; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5792909
• Synonyms: Il17ra^F
• Gene: Il17ra Location: Chr6:120440143-120460692 bp, + strand Genetic Position: Chr6, 56.95 cM
• Alliance: Il17ra^{tm1c(KOMP)Wtsi} page
• IMPC: Il17ra gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232695
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 120449477 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 120451075. A "conditional ready" (floxed) allele was be created by flp recombinase expression in mice, resulting in an allele where loxP sites flank exons 3 and 4 of the gene. (J:232695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17ra Mutation: 47 strains or lines available

References

• Original: J:232695 Wang K, et al., Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis. Immunity. 2014 Dec 18;41(6):1052-63
• All: 5 reference(s)