Csf2rb^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Csf2rb^{tm1c(EUCOMM)Hmgu}
• Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5792881
• Synonyms: Csf2rb^fl
• Gene: Csf2rb Location: Chr15:78210000-78235201 bp, + strand Genetic Position: Chr15, 37.36 cM
• Alliance: Csf2rb^{tm1c(EUCOMM)Hmgu} page
• IMPC: Csf2rb gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233647
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 78221919 of Chromosome 15 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 78223775. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, deleting the lacZ and meomycin expression cassettes. (J:233647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Csf2rb Mutation: 44 strains or lines available

References

• Original: J:233647 Croxford AL, et al., The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity. Immunity. 2015 Sep 15;43(3):502-14
• All: 11 reference(s)