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Ddah1tm1.1Geno
Targeted Allele Detail
Nomenclature
Symbol: Ddah1tm1.1Geno
Name: dimethylarginine dimethylaminohydrolase 1; targeted mutation 1.1, Genoway
MGI ID: MGI:5792874
Synonyms: DDAH1-
Gene: Ddah1  Location: Chr3:145758692-145894277 bp, + strand  Genetic Position: Chr3, 70.63 cM, cytoband H3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234529
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed exon 1 was removed. Western blot analysis confirmed the absence of protein expression in the kidney and liver. (J:234529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddah1 Mutation:  6 strains or lines available
References
Original:  J:234529 Dowsett L, et al., Endothelial Dimethylarginine Dimethylaminohydrolase 1 Is an Important Regulator of Angiogenesis but Does Not Regulate Vascular Reactivity or Hemodynamic Homeostasis. Circulation. 2015 Jun 23;131(25):2217-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory