Ccn4^tm1Mfy
Targeted Allele Detail

Summary

• Symbol: Ccn4^tm1Mfy
• Name: cellular communication network factor 4; targeted mutation 1, Marian F Young
• MGI ID: MGI:5792868
• Gene: Ccn4 Location: Chr15:66763337-66795050 bp, + strand Genetic Position: Chr15, 29.3 cM
• Alliance: Ccn4^tm1Mfy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233817
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An inverted neomycin resistance cassette was inserted into exon 2. Western blot analysis confirmed the absence of protein expression in hindlimb bones. (J:233817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccn4 Mutation: 32 strains or lines available

References

• Original: J:233817 Maeda A, et al., WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. J Biol Chem. 2015 May 29;290(22):14004-18
• All: 7 reference(s)