Kdm4c^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Kdm4c^{tm1c(KOMP)Wtsi}
• Name: lysine (K)-specific demethylase 4C; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5792835
• Gene: Kdm4c Location: Chr4:74160734-74324097 bp, + strand Genetic Position: Chr4, 36.06 cM
• Alliance: Kdm4c^{tm1c(KOMP)Wtsi} page
• IMPC: Kdm4c gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231987
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 74248471 of Chromosome 4 upstream of the critical exon 9 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the exon 9 at position 74249363. Exon 9 is flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice. (J:231987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm4c Mutation: 371 strains or lines available

References

• Original: J:231987 Pedersen MT, et al., The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol. 2014 Mar;34(6):1031-45
• All: 4 reference(s)