Mirc20^tm1.1Eem
Targeted Allele Detail

Summary

• Symbol: Mirc20^tm1.1Eem
• Name: microRNA cluster 20, including Mir302b through Mir367; targeted mutation 1.1, Edward E Morrisey
• MGI ID: MGI:5792833
• Synonyms: miR302-367^flox
• Gene: Mirc20 Location: Chr3:127338877-127339456 bp Genetic Position: Chr3, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233994
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the cluster of microRNAs. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of teh cluster. Flp-mediated recombination removed the selection cassette and left the cluster floxed. As confirmed by QRT-PCR, cre-mediated removal of the the microRNA cluster does not alter transcript expression of the host gene Larp6. (J:233994)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc20 Mutation: 1 strain or line available

References

• Original: J:233994 Tian Y, et al., A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015 Mar 18;7(279):279ra38
• All: 1 reference(s)