Ranbp9^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Ranbp9^{tm1c(EUCOMM)Hmgu}
• Name: RAN binding protein 9; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5792832
• Synonyms: Ranbp9^fl
• Gene: Ranbp9 Location: Chr13:43556151-43634758 bp, - strand Genetic Position: Chr13, 21.6 cM, cytoband A5
• Alliance: Ranbp9^{tm1c(EUCOMM)Hmgu} page
• IMPC: Ranbp9 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209420
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 43614741 of Chromosome 13 upstream of the exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 43615789. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette. leaving loxP sites flanking exon 3. (J:209420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ranbp9 Mutation: 40 strains or lines available

References

• Original: J:209420 Subramanian M, et al., An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. J Clin Invest. 2014 Mar 3;124(3):1296-308
• All: 1 reference(s)