Npc1l1^tm1Stky
Targeted Allele Detail

Summary

• Symbol: Npc1l1^tm1Stky
• Name: NPC1 like intracellular cholesterol transporter 1; targeted mutation 1, Hiroshi Suzuki
• MGI ID: MGI:5792802
• Synonyms: Npc1l1KO3TY/UT
• Gene: Npc1l1 Location: Chr11:6161013-6180143 bp, - strand Genetic Position: Chr11, 3.93 cM
• Alliance: Npc1l1^tm1Stky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233997
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1 and 2 and part of the promoter region. Western blot analysis confirmed the absence of protein expression in the intestine. (J:233997)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npc1l1 Mutation: 46 strains or lines available

References

• Original: J:233997 Takada T, et al., NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Sci Transl Med. 2015 Feb 18;7(275):275ra23
• All: 2 reference(s)