Hprt1^{tm8.1(CAG-ALPL)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm8.1(CAG-ALPL)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 8.1, Genoway
• MGI ID: MGI:5791065
• Synonyms: Hprt^ALPL, TNAP-OE
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm8.1(CAG-ALPL)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233357
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Hprt1^{tm8.1(CAG-ALPL)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ALPL (249)

  Alpl	(MGI:87983)

• Mutation details: The locus was targeted with a construct containing the ubiquitous CAG promoter, a floxed stop cassette and the human cDNA. The targeting construct also contains the promotor and exons of the human ortholog of the target locus, thus restoring the target locus. The stop cassette was removed through cre-mediated recombination, allowing the transcription of the inserted human cDNA. (J:233357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:233357 Sheen CR, et al., Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification. J Bone Miner Res. 2015 May;30(5):824-36
• All: 6 reference(s)