Dll1^{tm6.1(Dll3)Gos}
Targeted Allele Detail

Summary

• Symbol: Dll1^{tm6.1(Dll3)Gos}
• Name: delta like canonical Notch ligand 1; targeted mutation 6.1, Achim Gossler
• MGI ID: MGI:5790944
• Synonyms: Dll1^Dll3ki
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^{tm6.1(Dll3)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234164
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Duplication, Insertion
• Mutation details: A minigene containing the coding sequence of the inserted gene was coupled to genomic sequence containing the last three exons (3' part of exon 9 through entire exon 11) of the host gene. This combined sequence followed by a loxP-flanked neomycin resistance gene cassette was inserted at the ATG translation start site of the host gene. Subsequent cre-mediated recombination removed the neo cassette. Experiments confirm the functional expression of the inserted gene and knockout of the host gene. (J:234164)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:234164 Geffers I, et al., Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol. 2007 Jul 30;178(3):465-76
• All: 1 reference(s)