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Sfrp4tm1.1Lex
Targeted Allele Detail
Nomenclature
Symbol: Sfrp4tm1.1Lex
Name: secreted frizzled-related protein 4; targeted mutation 1.1, Lexicon Pharmaceuticals
MGI ID: MGI:5790103
Gene: Sfrp4  Location: Chr13:19623175-19632825 bp, + strand  Genetic Position: Chr13, 6.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234467
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe first exon was replaced by a loxP-flanked lacZ/Neo cassette which was removed via cre-mediated recombination. (J:234467)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sfrp4 Mutation:  12 strains or lines available
References
Original:  J:234467 Simsek Kiper PO, et al., Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N Engl J Med. 2016 Jun 30;374(26):2553-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory