Sfrp4^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Sfrp4^tm1.1Lex
• Name: secreted frizzled-related protein 4; targeted mutation 1.1, Lexicon Pharmaceuticals
• MGI ID: MGI:5790103
• Gene: Sfrp4 Location: Chr13:19807345-19816995 bp, + strand Genetic Position: Chr13, 6.99 cM
• Alliance: Sfrp4^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234467
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first exon was replaced by a loxP-flanked lacZ/Neo cassette which was removed via cre-mediated recombination. (J:234467)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfrp4 Mutation: 18 strains or lines available

References

• Original: J:234467 Simsek Kiper PO, et al., Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease. N Engl J Med. 2016 Jun 30;374(26):2553-62
• All: 2 reference(s)